@font-face{font-family:"Familjen Grotesk";src:url(/fonts/familjen-grotesk.woff2) format("woff2");font-weight:400 700;font-display:swap}
@font-face{font-family:"Source Serif 4";src:url(/fonts/source-serif-4.woff2) format("woff2");font-weight:200 900;font-display:swap}

:root{
  --ink:#14193a;      /* hematoxylin indigo */
  --blue:#2a6db5;     /* from the logo */
  --paper:#fbfcfe;
  --tint:#e9eff7;
  --line:#c9d5e4;
  --muted:#4b5674;
  --stain:#c2206a;    /* eosin magenta: reserved for what is lost */
  --stain-light:#ff7fb4;
  --sans:"Familjen Grotesk",system-ui,-apple-system,"Segoe UI",sans-serif;
  --serif:"Source Serif 4",Georgia,serif;
}
:lang(zh){
  --sans:"Familjen Grotesk","PingFang SC","Noto Sans CJK SC","Microsoft YaHei",sans-serif;
  --serif:"PingFang SC","Noto Sans CJK SC","Microsoft YaHei",sans-serif;
}

*,*::before,*::after{box-sizing:border-box}
html{-webkit-text-size-adjust:100%;scroll-padding-top:88px}
body{margin:0;background:var(--paper);color:var(--ink);font:400 1.0625rem/1.55 var(--sans)}
img,svg{display:block;max-width:100%;height:auto}
a{color:var(--blue);text-underline-offset:.18em;text-decoration-thickness:1px}
a:hover{color:var(--ink)}
:focus-visible{outline:3px solid var(--stain);outline-offset:2px}
h1,h2,h3{font-family:var(--sans);font-weight:600;line-height:1.08;letter-spacing:-.015em;margin:0;text-wrap:balance}
h2{font-size:clamp(1.75rem,3.2vw,2.5rem)}
h3{font-size:1.25rem;line-height:1.2;letter-spacing:0}
p{margin:0 0 1em}
ul,ol{margin:0;padding:0;list-style:none}
table{border-collapse:collapse;width:100%}
.sr{position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%);white-space:nowrap}
.skip{position:absolute;left:-999px;z-index:20;background:var(--ink);color:#fff;padding:8px 16px}
.skip:focus{left:8px;top:8px}
.wrap{max-width:1240px;margin-inline:auto;padding-inline:clamp(16px,4vw,40px)}
.scroll{overflow-x:auto;position:relative}

.draft{margin:0;padding:6px 16px;background:#fff0a8;color:var(--ink);font-size:.875rem;text-align:center}
mark.confirm{background:#fff0a8;color:var(--ink);box-shadow:0 0 0 2px #fff0a8;cursor:help}
mark.confirm a{color:inherit}

/* Header */
.top{position:sticky;top:0;z-index:10;background:var(--paper);border-bottom:1px solid var(--line)}
.top-in{display:flex;align-items:center;justify-content:space-between;gap:24px;min-height:68px}
.logo{display:flex;align-items:center;gap:10px}
.logo img:first-child{width:32px;height:auto}
.logo img:last-child{width:128px;height:auto}
.nav-wide{display:flex;gap:clamp(14px,2vw,28px)}
.top nav a{color:var(--ink);text-decoration:none;font-weight:500;font-size:1rem;padding-block:6px}
.top nav a:hover{color:var(--blue)}
.top nav a[aria-current]{box-shadow:0 2px 0 var(--stain)}
.nav-narrow{display:none;position:relative}
.nav-narrow summary{cursor:pointer;list-style:none;font-weight:600;padding:10px 0}
.nav-narrow summary::-webkit-details-marker{display:none}
.nav-narrow nav{position:absolute;right:0;top:100%;display:grid;gap:4px;min-width:200px;padding:12px 20px;background:var(--paper);border:1px solid var(--line)}
/* Language switch: a small capsule, like the buttons */
.langs{flex:none;margin:0;display:flex;padding:3px;border:1px solid var(--line);border-radius:999px;font-size:.875rem;line-height:1}
.langs a{padding:6px 12px;border-radius:999px;color:var(--muted);font-weight:500;text-decoration:none;transition:color .15s,background-color .15s}
.langs a:hover{color:var(--ink)}
.langs a[aria-current]{background:var(--ink);color:#fff}

/* Hero: the chromosome */
.hero{background:var(--ink);color:#fff;overflow:hidden}
.hero-top{display:grid;grid-template-columns:minmax(0,7fr) minmax(0,4fr);gap:clamp(24px,5vw,72px);align-items:end;padding-top:clamp(56px,9vw,120px);padding-bottom:clamp(96px,11vw,150px)}
.hero h1{font-size:clamp(2.75rem,6.4vw,5.5rem);line-height:1;letter-spacing:-.025em}
.hero-side p:first-child{font:400 1.1875rem/1.5 var(--serif);color:#dfe6f3}
.ctas{display:flex;flex-wrap:wrap;gap:12px;margin:0}
.hero-chr{margin:0;position:relative;padding-bottom:20px}
.hero-chr .chr{width:100%;height:clamp(52px,6.6vw,96px)}
.hero-chr figcaption{margin-top:14px;font-size:.875rem;color:#aebbd4}
.locus{position:absolute;left:var(--gap);bottom:100%;margin:0 0 -4px;padding:0 0 14px 12px;border-left:2px solid var(--stain-light);font-size:.9375rem;line-height:1.3;color:#fff;white-space:nowrap;transform-origin:bottom;animation:locus .5s .95s both}
.locus b{display:block;font-weight:600;color:var(--stain-light)}
.chr .gneg{fill:#e6ecf7}.chr .gpos25{fill:#b5c6e2}.chr .gpos50{fill:#8ba6d2}.chr .gpos75{fill:#6288c2}.chr .gpos100{fill:#3f6db0}
.chr .gvar{fill:#54699a}.chr .acen{fill:#8ea0c0}
.chr .lost{fill:var(--stain-light);animation:lost .7s .35s both ease-in}
.chr .gap{fill:none;stroke:var(--stain-light);stroke-width:1.5;stroke-dasharray:5 4;animation:fade .4s .9s both}
@keyframes lost{to{opacity:0;transform:translateY(-14px)}}
@keyframes fade{from{opacity:0}}
@keyframes locus{from{opacity:0;transform:scaleY(.6)}}

/* Buttons echo the chromosome's capsule */
.btn{display:inline-block;padding:11px 22px;border-radius:999px;background:var(--blue);color:#fff;font-weight:600;text-decoration:none;border:1.5px solid var(--blue)}
.btn:hover{background:var(--ink);border-color:var(--ink);color:#fff}
.btn.on-ink{background:#fff;border-color:#fff;color:var(--ink)}
.btn.on-ink:hover{background:var(--tint);border-color:var(--tint);color:var(--ink)}
.btn.on-ink.ghost{background:transparent;color:#fff;border-color:#8c99bd}
.btn.on-ink.ghost:hover{border-color:#fff;background:transparent;color:#fff}

/* Sections */
.sec{padding-block:clamp(56px,8vw,104px)}
.sec.tint{background:var(--tint)}
.sec.ink{background:var(--ink);color:#fff}
.sec.ink a:not(.btn){color:#a9c9f2}
.split{display:grid;grid-template-columns:minmax(0,4fr) minmax(0,8fr);gap:clamp(24px,5vw,72px);align-items:start}
.split+.wrap{margin-top:clamp(32px,5vw,56px)}
.head-row{display:flex;justify-content:space-between;align-items:baseline;gap:24px;margin-bottom:28px}
.prose{max-width:68ch;font:400 1.125rem/1.62 var(--serif)}
.prose h2{font-size:1.5rem;margin:1.6em 0 .5em}
.prose h3,.prose h4{margin:1.4em 0 .4em}
.prose ul,.prose ol{list-style:disc;padding-left:1.3em;margin-bottom:1em}
.prose li{margin-bottom:.4em}
.prose p:last-child{margin-bottom:0}
.sec.ink .prose{color:#e4eaf6}
.fine{margin-top:20px;max-width:80ch;font-size:.9375rem;line-height:1.5;color:var(--muted)}
.sec.ink .fine{color:#c0cbe2}
.page-head{padding-block:clamp(44px,7vw,84px) clamp(32px,4vw,52px);border-bottom:1px solid var(--line)}
.page-head h1{font-size:clamp(2.5rem,5.4vw,4.25rem);letter-spacing:-.025em}
.page-head p{max-width:46ch;margin:16px 0 0;font:400 1.25rem/1.45 var(--serif);color:var(--muted)}


/* Pipeline */
.pipe{min-width:760px}
.pipe th,.pipe td{text-align:left;vertical-align:top;padding:18px 20px 18px 0;border-bottom:1px solid var(--line)}
.pipe thead th{padding-block:0 10px;font-size:.9375rem;font-weight:500;color:var(--muted);border-bottom:2px solid var(--ink)}
.pipe tbody th{width:24%;font-size:1.25rem;font-weight:600}
.pipe tbody th a{color:inherit}
.pipe small{display:block;margin-top:2px;font-size:.9375rem;font-weight:400;color:var(--muted)}
.pipe td:nth-child(2){width:26%}
.pipe .stage-cell{padding-right:0}
.pipe thead .stages-h{padding-right:0}
.stages-h span{display:inline-block;width:25%;font-size:.875rem}
.track{display:grid;grid-template-columns:repeat(4,1fr);gap:4px;height:16px;margin-bottom:8px}
.track i{display:block;background:var(--tint)}
.track i:first-child{border-radius:8px 0 0 8px}
.track i:last-child{border-radius:0 8px 8px 0}
.track .done{background:var(--blue)}
.track .now{background:linear-gradient(90deg,var(--blue) var(--f),var(--tint) var(--f))}
.pipe td b{display:block}
.sec.tint .track i{background:#fff}
.stage-cell p{margin:0;font-size:.9375rem;line-height:1.4;color:var(--muted)}
.partnered .track .done{background:#7f9fc9}
.partnered .track .now{background:linear-gradient(90deg,#7f9fc9 var(--f),var(--tint) var(--f))}

/* Forest plot */
.forest{min-width:760px;margin-top:clamp(28px,4vw,44px);color:#fff}
.forest caption{text-align:left;padding-bottom:14px;font-size:1rem;font-weight:600}
.forest th,.forest td{text-align:left;padding:13px 16px 13px 0;border-bottom:1px solid #3a4470;font-weight:400;vertical-align:middle}
.forest thead th{padding-top:0;font-size:.9375rem;color:#c0cbe2;vertical-align:bottom}
.forest tbody th{font-weight:600;width:24%}
.forest td:nth-child(n){font-variant-numeric:tabular-nums}
.forest .num{white-space:nowrap}
.forest .axis,.forest .plot{width:38%;padding-right:18px}
.ticks{position:relative;height:18px}
.ticks span{position:absolute;transform:translateX(-50%);font-size:.8125rem}
.lane{position:relative;height:24px;background:linear-gradient(90deg,#3a4470 1px,transparent 1px) 0 0/25% 100%;border-right:1px solid #3a4470}
.ci,.pt{position:absolute;top:50%}
.ci{height:2px;margin-top:-1px;background:#a9c9f2}
.pt{width:12px;height:12px;margin:-6px 0 0 -6px;border-radius:50%;background:#fff;box-shadow:0 0 0 2px var(--ink)}
.cols3{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:clamp(20px,3vw,40px);margin-top:clamp(28px,4vw,44px)}
.cols3 h3{margin-bottom:8px}
.cols3 p{margin:0;color:#e4eaf6}
.cols2{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:32px}
address{font-style:normal}


/* Tables and lists */
.defs{margin:0;display:grid;grid-template-columns:minmax(0,3fr) minmax(0,7fr);column-gap:32px}
.defs dt,.defs dd{margin:0;padding-block:14px;border-bottom:1px solid var(--line)}
.defs dt{font-weight:600}
.defs dd{font:400 1.0625rem/1.55 var(--serif)}
.defs+.prose{margin-top:28px}
.facts{margin:24px 0;display:grid;grid-template-columns:auto 1fr;gap:6px 24px}
.facts dt{font-weight:600}.facts dd{margin:0}
.fig{margin:28px 0 0;max-width:720px}
.fig img{width:100%;mix-blend-mode:multiply}
.fig figcaption{margin-top:10px;font-size:.9375rem;line-height:1.45;color:var(--muted)}
.sub{margin-top:clamp(40px,5vw,64px)}
.sub+*{margin-top:18px}
.figs{align-items:start}
.figs .fig{margin-top:0;max-width:none}
.bars{max-width:620px;margin-top:32px}
.bars caption{text-align:left;padding-bottom:10px;font-weight:600}
.bars th,.bars td{padding:7px 14px 7px 0;border-bottom:1px solid var(--line);text-align:left;font-weight:400;white-space:nowrap}
.bars .num{text-align:right;font-variant-numeric:tabular-nums}
.bars td:last-child{width:55%;padding-right:0}
.bars i{display:block;height:14px;border-radius:0 4px 4px 0;background:var(--blue)}

.people{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:clamp(36px,5vw,56px) clamp(24px,3.5vw,44px)}
.people img{width:100%;aspect-ratio:1;object-fit:cover;object-position:50% 18%;background:var(--tint);margin-bottom:14px}
.people h2{font-size:1.375rem;letter-spacing:0}
.people .role{margin:4px 0 10px;color:var(--blue);font-weight:500}
.people p:last-child{margin:0;font:400 1rem/1.55 var(--serif)}

.timeline{display:grid}
.timeline li{display:grid;grid-template-columns:80px 1fr;gap:16px;padding-block:14px;border-bottom:1px solid var(--line)}
.timeline time{font-weight:600;font-size:1.25rem;color:var(--blue)}
.timeline p{margin:0;max-width:60ch;font:400 1.0625rem/1.55 var(--serif)}

.news li{display:grid;grid-template-columns:170px 90px 1fr;gap:16px;align-items:baseline;padding-block:15px;border-bottom:1px solid var(--line)}
.news time,.tag{font-size:.9375rem;color:var(--muted)}
.news a{font-weight:500;font-size:1.125rem;line-height:1.3;color:var(--ink);text-decoration-color:var(--line)}
.news a:hover{color:var(--blue)}

.pres li{display:grid;grid-template-columns:200px 1fr;gap:clamp(20px,3vw,36px);padding-block:26px;border-bottom:1px solid var(--line)}
.pres li:first-child{padding-top:0}
.thumb img{width:100%;border:1px solid var(--line)}
.pres h2{font-size:1.375rem;line-height:1.2;letter-spacing:0;margin-bottom:8px;max-width:48ch}
.pres p{margin:0 0 6px}
.meta{font-size:.9375rem;color:var(--muted)}
.article{max-width:800px}
.article h1{font-size:clamp(1.875rem,3.6vw,2.625rem);line-height:1.12;margin-bottom:12px}
.article .prose{margin-top:28px;overflow-wrap:anywhere}

/* Footer */
.foot{background:var(--ink);color:#d9e1f0;padding-block:48px 28px;font-size:.9375rem}
.foot a{color:#fff}
.foot strong{display:block;margin-bottom:6px;color:#fff}
.foot address,.foot p{margin:0 0 10px}
.foot-in{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:32px}
.foot-base{margin-top:32px;padding-top:18px;border-top:1px solid #3a4470;font-size:.875rem;color:#aebbd4}
.foot-base p{max-width:90ch}
.foot-base a{margin-left:10px;color:#aebbd4}

/* Chinese: no tracking or slanted Han, looser leading, and measures in em because ch is half a Han character */
:lang(zh) :is(h1,h2,h3){letter-spacing:0;line-height:1.3}
:lang(zh) .hero h1{font-size:clamp(2.5rem,5.6vw,4.75rem);line-height:1.2}
:lang(zh) :is(.prose,.defs dd,.people p:last-child,.timeline p){line-height:1.75}
:lang(zh) .prose{max-width:40em}
:lang(zh) .page-head p{max-width:30em}
:lang(zh) .fine{max-width:48em}
:lang(zh) em{font-style:normal}

@media (max-width:1040px){
  .nav-wide{display:none}.nav-narrow{display:block}
  .hero-top{grid-template-columns:1fr}
}
@media (max-width:760px){
  body{font-size:1rem}
  .split{grid-template-columns:1fr}
  .cols3,.cols2,.foot-in{grid-template-columns:1fr}
  .people{grid-template-columns:repeat(2,minmax(0,1fr))}
  .news li{grid-template-columns:1fr auto}
  .news a{grid-column:1/-1}
  .pres li{grid-template-columns:1fr}
  .thumb{max-width:220px}
  .pipe,.forest{min-width:0}
  .pipe,.pipe tbody,.pipe tr,.pipe th,.pipe td,.forest,.forest thead,.forest tbody{display:block}
  .pipe thead{position:absolute;width:1px;height:1px;overflow:hidden;clip-path:inset(50%)}
  .pipe tr{padding-block:16px;border-bottom:1px solid var(--line)}
  .pipe tbody th,.pipe td,.pipe td:nth-child(2){width:auto;padding:0 0 8px;border:0}
  .forest caption{display:block}
  .forest thead tr{display:block}
  .forest thead th:not(.axis){display:none}
  .forest .axis{display:block;width:auto;padding:0 12px 8px 0;border-bottom:1px solid #3a4470}
  .forest tbody tr{display:grid;grid-template-columns:1fr auto;gap:2px 12px;padding-block:10px;border-bottom:1px solid #3a4470}
  .forest tbody th,.forest tbody td{padding:0;border:0;width:auto}
  .forest tbody th{grid-column:1/-1;padding-top:6px}
  .forest .plot{grid-column:1/-1;padding-right:12px}
  .forest .num{font-weight:600}
  .defs{grid-template-columns:1fr}
  .defs dt{padding-bottom:0;border-bottom:0}
  .defs dd{padding-top:4px}
}
@media (max-width:460px){
  .top-in{gap:10px}
  .logo img:last-child{width:112px}
  .langs a[aria-current]{display:none}
  .people{grid-template-columns:1fr}
  .people img{max-width:280px}
  .timeline li{grid-template-columns:60px 1fr}
}
@media (prefers-reduced-motion:reduce){
  *,*::before,*::after{animation-duration:.01ms!important;animation-delay:0s!important}
}